CURRICULUM VITAE

LEJLA FERHATOVIĆ HAMZIĆ

h-indeks: 10

Radno iskustvo

  •  Lipanj 2021. – Stručna savjetnica na projektu „Individualizirani pristup u predikciji razvoja dijabetesa“; Laboratorij za kemijsku analitiku pri Centru za primijenjenu bioantropologiju; Institut za antropologiju 
  • Siječanj 2019. – Travanj 2021. Poslijedoktorandica na projektu „Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu“; Odjel za proteomiku pri Centru za translacijska i klinička istraživanja; Medicinski fakultet Sveučilišta u Zagrebu
  • Ožujak 2018. – Prosinac 2018. Poslijedoktorandica na projektu Hrvatske zaklade za znanost „ BMP1-IsoFor“; Odjel za proteomiku pri Centru za translacijska i klinička istraživanja; Medicinski fakultet Sveučlišta u Zagrebu
  • Listopad 2016.- Studeni 2017.  Porodiljni dopust 
  • Studeni 2015. – Listopad 2016. Poslijedoktorandica na projektu Hrvatske zaklade za znanost „Osciton”; Zavod za molekularnu biologiju;Institut Ruđer Bošković, Zagreb
  • Ožujak 2013. – Listopad 2015. Poslijedoktorandica na EU FP7 projektu „Glowbrain”; Hrvatski institut za istraživanje mozga; Medicinski fakultet Sveučilišta u Zagrebu 
  • Rujan 2010. -Veljača 2013. Doktorandica na projektu Hrvatske zaklade za znanost „Memodin“; Zavod za anatomiju, histologiju i embriologiju; Medicinski fakultet Sveučilišta u Splitu

 Obrazovanje

  • Travanj 2013. Doktorski studij: Translacijska istraživanja u biomedicini i zdravstvu pri Medicinskom fakultetu Sveučilišta u Splitu
  • Listopad 2009. Diplomski studij: Kemijsko inženjerstvo u zaštiti okoliša pri Kemijsko-tehnološkom fakultetu u Splitu

Tečajevi i stručna usavršavanja 

  1. Znanstveno usavršavanje u metodama molekularne biologije: phage display, izolacija DNA, Southern blot, 01. travanj- 01. rujan 2019. Genera istraživanja, Biocentar, Zagreb.
  2. LabAnim tečaj za rad sa laboratorijskim životinjama. 05.-15. lipanj 2018. PMF, Odjel za biologiju, Zagreb.
  3. Radionica: Uvod u tekuću i plinsku kromatografiju. 15. srpanj 2018. Biocentar, Zagreb.
  4. Radionica projekta Interbio: Dinamika citoskeleta. 14.-15. srpanj 2016. Zagreb.
  5. Druga radionica EU FP7 REGPOT projekta Polaris: Prozivodnja i nanokarakterizacijske tehnike u razvoju nanosistema za korištenje u biomedicini. 20.-22. listopad 2014. Porto, Portugal.
  6. Radionica Medicinskog centra Ceders-Sinai i Udruge RECOOP HST: Zaštiti i publiciraj. 28.-29. svibanj 2014. Split.
  7. Radionica EU FP7 projekta Glowbrain: Korištenje biomaterijala i in vivo oslikavanje u istraživanju matičnih stanica. Ožujak 27.- 29. 2014. Zagreb.
  1. Znanstveno usavršavanje u Institutu za makromolekularnu kemiju akademije za znanost. 04. studeni – 18. prosinac 2013. Prag, Republika Češka.
  2. Radionica EU FP7 projekta Glowbrain: Korištenje neuralnih matičnih stanica i mišjih modela u neuroznanosti.  02. -05. listopad 2013. Zagreb.
  3. Znanstveno usavršavanje istraživačkom centru 3B’s pri Zavodu za polimerno inženjerstvo Sveučilišta Minho. 17. lipanj – 31. srpanj 2013. Caldas das Taipas, Portugal.
  4. Radionica EU FP7 projekta Glowbrain: Tehnike istraživanja matičnih stanica.  23.-25. svibanj. 2013., Zagreb.
  5. Drugi tečaj organizacije COST: Action NAMABIO MP1005: Od nano- do makro- biomaterijala (dizajn, obrada, karakterizacija, modeliranje) i korištenje u regenerativnoj ortopediji i dentalnoj medicini. 08.-11. travanj  2013., Ankona, Italija.
  6. Zajednička škola udruženja FENS i IBRO: Evolucijski koncepti boli. Lipanj 2012. Siena, Italija.
  7. Trening pretraživanja znanstvenih baza podataka. Svibanj 2012. Split.
  8. Methodološki tečajevi u biologiji i medicini „DNA i RNA“ Institut Ruđer Bošković, Zagreb.
  9. Opći tečaj o intelektualnom vlasništvu. Svjetska organizacija za intelektualno vlasništvo. Internetski tečaj. Travanj i svibanj 2011.

Znanstveno iskustvo

  • Medicina: in vivo životinjski modeli moždanog udara, boli i dijabetesa, proizvodnja poliklonskih protutijela, analiza rezultata kliničkih ispitivanja, fluorescentna i svjetlosna mikroskopija, konfokalna mikroskopija, histologija, imunohistokemija.
  • Kemija: spektrofotometrija, sinteza nanočestica, fizikalna i kemijska karakterizacija nanomaterijala i hidrogelova, HPLC/MS.
  • Molekularna biologija: western blot, ELISA, imunocitokemija, konfokalna mikroskopija živih stanica, in vitro uzgoj u dvodimenzionalnim i trodimenzionalnim sustavima, proliferacijski testovi i testovi preživljenja, phage display.
  • Kompjutorski programi: MS Office paket programa, Adobe Illustrator, Adobe Photoshop, Metamorph, ImageJ, GraphPad, EndNote
  • Samostalna analiza dobivenih rezultata, pisanje znanstvenih radova i znanstvenih izviješća

 Predavačko iskustvo

  • -2020. poslijediplomski studij Stomatološkog fakulteta Sveučilišta u Zagrebu
  • -2012. Zavod za istraživanja u biomedicini i zdravstvu Medicinskog sveučilišta u Splitu

Članstvo u profesionalnim udruženjima

  • Hrvatsko društvo neuroznanosti
  • Hrvatski liječnički zbor
  • Savez europskih neuroznanstvenih udruženja (FENS)

Znanstveni radovi

  1. Vuka I, Marciuš T, Došenović S, Ferhatović Hamzić L, Vučić K, Sapunar D, Puljak L. Efficacy and Safety of Pulsed Radiofrequency as a Method of Dorsal Root Ganglia Stimulation in Patients with Neuropathic Pain: A Systematic Review.Pain Med. 2020 Dec 25;21(12):3320-3343.
  2. Grgurevic L, Novak R, Trkulja V, Hrkac S, Salai G, Bilandzic J, Hamzic LF, Milas I, Vucemilo T, Balja MP, Bilic K. Plasma levels and tissue expression of soluble TGFβrIII receptor in women with early-stage breast cancer and in healthy women: a prospective observational study. J Transl Med. 2020 Dec 11;18(1):478.
  3. Vuka I, Došenović S, Marciuš T, Ferhatović Hamzić L, Vučić K, Sapunar D, Puljak L. Efficacy and safety of pulsed radiofrequency as a method of dorsal root ganglia stimulation for treatment of non-neuropathic pain: a systematic review. BMC Anesthesiol. 2020 May 4;20(1):105.
  4. Kostic S, Williams B, Ksouri S, Hardung L, Filipovic N, Hamzic LF, Puljak L,  hahramani N, Vukojevic K. Changes in snail and SRF expression in the kidneys of diabetic rats during ageing. Acta Histochem. 2020 Jan;122(1):151460.
  5. Grgurević L, Novak R, Trkulja V, Hamzić LF, Hrkač S, Grazio S, Santini M. Elevated plasma RANTES in fibrodysplasia ossificans progressiva – A novel therapeutic target? Med Hypotheses. 2019 Oct;131:109313.
  6. Vuka I, Marciuš T, Došenović S, Ferhatović Hamzić L, Vučić K, Sapunar D, Puljak L. Neuromodulation with electrical field stimulation of dorsal root ganglion in various pain syndromes: a systematic review with focus on participant selection. J Pain Res. 2019 Feb 27;12:803-830.
  7. Delic Jukic IK, Kostic S, Filipovic N, Gudelj Ensor L, Ivandic M, Dukic JJ, Vitlov Uljevic M, Ferhatovic Hamzic L, Puljak L, Vukojevic K. Changes in expression of special AT-rich sequence binding protein 1 and phosphatase and tensin homologue in kidneys of diabetic rats during ageing. Nephrol Dial Transplant. 2018 Oct 1;33(10):1734-1741.
  8. Vuka I, Vučić K, Repić T, Ferhatović Hamzić L, Sapunar D, Puljak L. Electrical Stimulation of Dorsal Root Ganglion in the Context of Pain: A Systematic Review of In Vitro and In Vivo Animal Model Studies. Neuromodulation. 2018 Apr;21(3):213-224.
  9. Bakovic M, Filipovic N, Ferhatovic Hamzic L, Kunac N, Zdrilic E, Vitlov Uljevic M, Kostic S, Puljak L, Vukojevic K. Changes in neurofilament 200 and tyrosine hydroxylase expression in the cardiac innervation of diabetic rats during aging. Cardiovasc Pathol. 2018 Jan-Feb;32:38-43.
  10. Pospisil T, Ferhatovic Hamzic L, Brkic Ahmed L, Lovric M, Gajovic S, Frkanec L. Synthesis, characterization and in vitro biocompatibility assessment of a novel tripeptide hydrogelator, as a promising scaffold for tissue engineering applications. Biomaterials Science. 4 (2016) , 10; 1412-1416
  11. Patsula V, Kosinova L, Lovric M, Ferhatović Hamzic L, Rabyk M, Konefal R, Paruzel A, Slouf M, Herynek V, Gajovic S,  Horak D. Superparamagnetic Fe3O4 Nanoparticles: Synthesis by Thermal Decomposition of Iron(III) Glucuronate and Application in Magnetic Resonance Imaging.  ACS Applied Materials & Interfaces. 8 (2016) , 11; 7238-724
  12. Vuica A, Vukojevic K, Ferhatovic Hamzic L, Jeric M, Puljak L, Grkovic I, Filipovic N. Expression pattern of CYP24 in liver during ageing in long-term diabetes. Acta Histochemica. 118 (2016) ; 486-495
  13. Vinkovic Vrcek I, Pavicic I, Crnkovic T, Jurasin D, Babic M, Horak D, Lovric M, Ferhatovic L, Curlin M, Gajovic S. Does surface coating of metallic nanoparticles modulate their interferences with in vitro assays? RSC Advances. 5 (2015) ; 70787-70807
  14. Vuica A, Ferhatovic Hamzic L, Vukojevic K, Jeric M, Puljak L, Grkovic I, Filipovic N. Aging and chronic diabetes mellitus increase expression of 1 α-hydroxylase and vitamin D receptors in the rat liver. Experimental gerontology. 72 (2015) ; 167–176
  15. Masek T, Filipovic N, Hamzic LF, Puljak L, Starcevic K. Long-term streptozotocin diabetes impairs arachidonic and docosahexaenoic acid metabolism and ∆5 desaturation indices in aged rats. Experimental gerontology. 2014 Dec;60:140-6.
  16. Jelicic Kadic A, Boric M, Vidak M, Ferhatovic L, Puljak L. Changes in epidermal thickness and cutaneous innervation during maturation in long-term diabetes. J Tissue Viability. 2014 Feb;23(1):7-12.
  17. Ferhatovic L, Jelicic Kadic A, Boric M, Puljak L. Changes of calcium/calmodulin-dependent protein kinase II expression in dorsal root ganglia during maturation in long-term diabetes. Hystology and Histopathology. 2014 May;29(5):649-58.
  18. Boric M, Kadic AJ, Ferhatovic L, Sapunar S, Puljak L. Calcium/calmodulin-dependent protein kinase II in dorsal horn neurons in long-term diabetes. 2013 Dec 4;24(17):992-6.
  19. Bakovic M, Juric Paic M, Zdrilic E, Vukojevic K, Ferhatovic L, Marin A, Filipovic N, Grkovic I, Puljak Changes in cardiac innervation during maturation in long-term diabetes. Experimental Gerontology. 2013 Dec;48(12):1473-8.
  20. Boric M, Skopljanac I, Ferhatovic L, Jelicic Kadic A, Banozic A, Puljak L. Reduced epidermal thickness, nerve degeneration and increased pain-related behavior in rats with diabetes type 1 and 2. J Chem Neuroanat. 2013 Nov;53:33-40.
  21. Jelicic Kadic A, Boric M, Ferhatovic L, Banozic A, Sapunar D, Puljak L. Intrathecal inhibition of calcium/calmodulin-dependent protein kinase II in diabetic neuropathy adversely affects pain-related behavior. Neuroscience Letters. 2013 Oct 25;554:126-30.
  22. Filipovic N, Ferhatovic L, Marelja I, Puljak L, Grkovic I. Increased vitamin D receptor expression in dorsal root ganglia neurons of diabetic rats. Neurosci Lett. 2013 Aug 9;549:140-5.
  23. Yu H, Fischer G, Ferhatovic L, Fan F, Light AR, Weihrauch D, Sapunar D, Nakai H, Park F, Hogan QH. Intraganglionic AAV6 Results in Efficient and Long-Term Gene Transfer to Peripheral Sensory Nervous System in Adult Rats. PLoS One. 2013 Apr 16;8(4):e61266.
  24. Novak A, Rezic Muzinic N, Vedrana Cikes-Culic V, Bozic J, Tina Ticinovic Kurir T, Ferhatovic L, Puljak L, Markotic A. Renal distribution of ganglioside GM3 in rat models of type 1 and type 2 diabetes. J Physiol Biochem. 2013 Dec;69(4):727-35.
  25. Cosic A, Ferhatovic L, Banozic A, Kraljevic S, Maric A, Sapunar D, Puljak L. Pain catastrophizing changes during the menstrual cycle. Psychol Health Med. 2013;18(6):735-41. 26.
  26. Ferhatovic L., Banozic A, Kostic S, Sapunar D, Puljak L. Sex differences in pain-related behavior and expression of calcium/calmodulin-dependent protein kinase II in dorsal root ganglia of rats with diabetes type 1 and type 2. Acta Histochemica. 2013 Jun;115(5):496-504.
  27. Ferhatovic L, Banozic A, Kostic S, Ticinovic Kurir T, Novak A, Vrdoljak L, Heffer M, Sapunar D, Puljak L, Expression of calcium/calmodulin-dependent protein kinase II and pain-related behavior in rat models of type 1 and type 2 diabetes. Anestesia & Analgeisa. 2013 Mar;116(3):712-21
  28. Klinar I, Ferhatovic L, Banozic A, Raguz M, Kostic S, Sapunar D, Puljak L. Physicians’ attitudes about interprofessional treatment of chronic pain: family physicians are considered the most important collaborators. Scandinavian Journal of Caring Sciences. 2013 Jun;27(2):303-10.
  29. Sapunar D, Kostic S, Banozic A, Ferhatovic L, Puljak L. Pain research in Croatia: Analysis of bibliometric trends. Periodicum biologorum. 2011;113(2):137-140.
Sažetci sa kongresa
  1. Politeo O, Carev I, Ferhatovic Hamzic L. Expression of superoxide dismutase enzyme in stress conditions. Book of Abstracts Special Issue of Bulletin of the Chemists and Technologists of Bosnia and Herzegovina, 2016. 18, Sarajevo, Bosnia and Herzegovina
  2. Lovric M, Ferhatovic Hamzic L, Boban M, Oliveira ML, Reis RL, Gajovic S. Application of Biomaterials for the Treatment of Stroke: In vivo Preclinical Studies. EU FP7 Project Glowbrain Final Conference Stem Cell and Biomaterial Applications for Brain Repair. May 27-30, 2015 Zagreb, Croatia
  3. Ferhatovic Hamzic L, Pospisil T, Frkanec L, Lovric M, Gajovic S. Development and in vitro Biocompatibility Assessment of Novel Supramolecular Hydrogel Biomaterial. EU FP7 Project Glowbrain Final Conference Stem Cell and Biomaterial Applications for Brain Repair. May 27-30, 2015 Zagreb, Croatia
  4. Vinkovic Vrcek I, Lovric M, Ferhatovic Hamzic L, Horak D, Gajovic S. In vitro protocols for the evaluation of biocompatibility of metallic nanoparticles. EU FP7 Project Glowbrain Final Conference Stem Cell and Biomaterial Applications for Brain Repair. May 27-30, 2015 Zagreb, Croatia
  5. Ferhatovic Hamzic L, Pospisil T, Frkanec L, Lovric M, Gajovic S. Characterization and in vitro biocompatibility assessment of newly developed supramolecular gel. 24th Croatian Meeting of Chemists and Chemical Engineers. April 21-24, 2015 Zagreb, Croatia
  6. Lovric M, Ferhatovic Hamzic L, Zuntar I, Gajovic S, Horak D, Vinkovic Vrcek I. Interferences of Metal-Based Nanoparticles with Fluorescent Probes Used for In Vitro Testings. TERM STEM 2014: NanoTools for diagnosis and regeneration of tissues, Conference, Porto, Portugal, 2014.
  7. Lovric M, Ferhatovic Hamzic L, Jurasin D, Gajovic S, Horak D, Vinkovic Vrcek I, Stability of Metal-Based Nanoparticles in Cell Culture Medium, TERM STEM 2014: „NanoTools for diagnosis and regeneration of tissues“, Conference, Porto, Portugal, 2014.
  8. Ferhatovic Hamzic L, Pospisil T, Brkic L, Lovric M, Frkanec L, Gajovic S: In vitro platform for screening the potential use of supramolecular gels to support neural stem cells as a treatment in a mouse model of brain ischemic stroke, Training school Cost Action NamaBio MP1005-4th Course, Nicosia, Cyprus, October, 2014.
  9. Pongrac I, Dobrivojevic M, Babic M, Lovric M, Ferhatovic Hamzic L, Slouf M, Gajovic S, Horak D. In vitro evaluation of poly(L-lysine)-coated maghemite nanoparticles: Application in brain research, Congress of the Croatian Society of Biochemistry and Molecular Biology – HDBMB2014 entitled The Interplay of Biomolecules Zadar, Croatia, 2014.
  10. Ferhatovic Hamzic L, Lovric M, Pongrac I, Bozza A, Casarosa S, Gajovic S: Combination of biomaterials and stem cells for brain transplantation after ischemic injury in mouse, 78th Prague Meeting on Macromolecules, Frontiers of Polymer Colloids: From Synthesis to macro-scale and nano-scale applications, Conference, Prague, Czech Republic, 2014.
  11. Lovric M, Ferhatovic Hamzic L, Patsula V, Gajovic S, Horak D. Synthesis of Novel PEG-coated Iron Oxide Nanoparticles via Thermal Decomposition Approach. EU FP7 Project GlowBrain Workshop: Application of biomaterials and in vivo imaging in stem cell research, Zagreb, Croatia, 2014.
  12. Lovric M, Ferhatovic L, Polsek D, Kosi N, Brkic L, Alic I, Pochet R, Casarosa S,  Gajovic S. Mouse fetal neural stem cell preparation and brain transplantation using alginate hydrogels. TERM STEM 2013; Nanotechnology as a Tool for improving Tissue Engineering and Regenerative Medicine Conference, Porto, Portugal, 2013. (J. Tissue Eng. Regen. Med. (2013), 7 (Supp. 1): 6–52, page 29, oral presentation: S. Gajovic)
  13. Ferhatovic Hamzic L, Lovric M, Casarosa S, Gajovic S, Alginate a stable and biocompatible stem cells-seeded hydrogel carrier for the targeted delivery in the stroke lesion. Bridges in Life Sciences 9th Annual Scientific Conference, May 27-June 1 2014, Split, Croatia.
  14. Jelicic Kadic A, Boric M, Ferhatovic L, Banozic A, Sapunar D, Puljak L. Intrathecal inhibition of calcium/calmodulin protein kinase II in diabetic neuropathy adversly affects pain-related behavior, RECOOP Annual Project Review Meeting October 10-13, 2013. Split, Croatia
  15. Lovric M, Ferhatovic L, Polsek D, Kosi N, Brkic L, Alic I, Pochet R, Casarosa S, Gajovic. Mouse fetal neural stem cell preparation and brain transplantation using alginate hydrogels. TERM STEM 2013 Nanotechnology as a Tool for improving Tissue Engineering and Regenerative Medicine, 10-12 October 2013 Porto, Portugal
  16. Lovric M, Ferhatovic L, Polsek D, Kosi N, Brkic L, Alic I, Pochet R, Casarosa S, Gajovic S. 3D culture of mouse neuronal stem cells in calcium alginate beads. Croatian Neuroscience Congress. September 20-21, 2013 Zagreb, Croatia
  17. Ferhatovic L, Jelicic AK, Boric M, Banozic A, Sapunar D, Puljak L. Long-term changes in expression of calcium/calmodulin protein kinase II in dorsal root ganglia neurons of STZ-diabetic rats. Croatian Neuroscience Congress. September 20-21, 2013 Zagreb, Croatia
  18. Ferhatovic L, Jelicic A, Boric M, Banozic A, Sapunar D, Puljak L. Expression of calcium/calmodulin-dependent protein kinase II in dorsal root ganglia in diabetic rats 6 months and 1 year after diabetes induction Scandinavian Association for the Study of Pain 2013, Helsinki, 13-15 June 2013
  19. Cosic A, Ferhatovic L, Banozic A, Kraljevic S, Maric A, Sapunar D, Puljak L. Pain catastrophizing changes during menstrual cycle, 14th World congress on pain, August 27-31, 2012, Milan, Italy.
  20. Ferhatovic L, Banozic A, Kostic S, Ticinovic Kurir T, Novak A, Vrdoljak L, Sapunar D, Puljak L. Sensory changes and increase of calcium/calmodulin –dependent protein kinase II expression in animal models of diabetes type 1 and 2, 14th World congress on pain, August 27-31, 2012, Milan, Italy.
  21. Rezic Muzinic N, Cikes Culic V, Radan M, Mastelic A, Delic H, Ferhatovic L, Puljak L, Markotic A. Renal globotetraosylceramide expression in rat model of diabetes type 1. FEBS3+ Meeting From Molecules to Life and Back. June 13-16, 2012. Opatija, Croatia.
  22. Ferhatovic L, Kostic S, Banozic A, Vrdoljak L, Sapunar D, Puljak L. A role of calcium/calmodulin-depedent protein kinase II in diabetic neuropathy. Invited oral presentation. Bridges in Life Sciences 7th Annual Conference: Science and Art for the Advancement in Medicine. March 30 – April 1, 21012. Budapest, Hungary.
  23. Ferhatovic L, Kostic S, Banozic A, Sapunar D, Puljak L, A role of the calcium/calmodulin-dependent protein kinase II in diabetic neuropathy,7th Congress of the European Federation of IASP Chapters (EFIC), September, 2011.Hamburg, Germany.
  24. Ferhatovic L, Banozic A, Kostic S, Sapunar D, Puljak L. Role of Calcium/Calmodulin-Dependent Protein Kinase II in the diabetic neuropathy. Young Neuroscientists Meeting (YNM). June, 2011. Trieste, Italy.
  25. Carev I, Ferhatovic L, Politeo O, Burcul F, Jukic M, Milos M. Biological activitiy of non-volatile compounds of plants in Asteraceae family. International symposium XIII. Ruzicka’s Days “Science today – industry tomorrow”. September, 2010. Vukovar, Croatia.

Znanje stranih jezika: Engleski pisanje/čitanje/razumijevanje: napredno